Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma.

ABSTRACT:

Background

Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission, especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from lethal stage 4 can be difficult, but critical for therapeutic decisions. The aim of this study was to investigate chromosomal alterations and differential gene expression amongst infant disseminated NB subgroups.

Methods

Thirty-five NB tumours from patients diagnosed at < 18 months (25 stage 4 and 10 stage 4s), were evaluated by allelic and gene expression analyses.

Results

All stage 4s patients underwent spontaneous remission, only 48% stage 4 patients survived despite combined modality therapy. Stage 4 tumours were 90% near-diploid/tetraploid, 44% MYCN amplified, 77% had 1p LOH (

SUBMITTER: Lavarino C 

PROVIDER: S-EPMC2642835 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature