Trans-regulation of mouse meiotic recombination hotspots by Rcr1.

ABSTRACT: Meiotic recombination is required for the orderly segregation of chromosomes during meiosis and for providing genetic diversity among offspring. Among mammals, as well as yeast and higher plants, recombination preferentially occurs at highly delimited chromosomal sites 1-2 kb long known as hotspots. Although considerable progress has been made in understanding the roles various proteins play in carrying out the molecular events of the recombination process, relatively little is understood about the factors controlling the location and relative activity of mammalian recombination hotspots. To search for trans-acting factors controlling the positioning of recombination events, we compared the locations of crossovers arising in an 8-Mb segment of a 100-Mb region of mouse Chromosome 1 (Chr 1)

SUBMITTER: Parvanov ED 

PROVIDER: S-EPMC2642880 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature