Design and synthesis of vidarabine prodrugs as antiviral agents.

ABSTRACT: 5'-O-D- and L-amino acid derivatives and 5'-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake by cultured cells was improved compared to the parent drug.

SUBMITTER: Shen W 

PROVIDER: S-EPMC2642980 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature