Development and preliminary evaluation of a multivariate index assay for ovarian cancer.

ABSTRACT:

Background

Most women with a clinical presentation consistent with ovarian cancer have benign conditions. Therefore methods to distinguish women with ovarian cancer from those with benign conditions would be beneficial. We describe the development and preliminary evaluation of a serum-based multivariate assay for ovarian cancer. This hypothesis-driven study examined whether an informative pattern could be detected in stage I disease that persists through later stages.

Methodology/principal findings

Sera, collected under uniform protocols from multiple institutions, representing 176 cases and 187 controls from women presenting for surgery were examined using high-throughput, multiplexed immunoassays. All stages and common subtypes of epithelial ovarian cancer, and the most co

SUBMITTER: Amonkar SD 

PROVIDER: S-EPMC2643010 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature