Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study.

ABSTRACT:

Background

Human and animal prion diseases are under genetic control, but apart from PRNP (the gene that encodes the prion protein), we understand little about human susceptibility to bovine spongiform encephalopathy (BSE) prions, the causal agent of variant Creutzfeldt-Jakob disease (vCJD).

Methods

We did a genome-wide association study of the risk of vCJD and tested for replication of our findings in samples from many categories of human prion disease (929 samples) and control samples from the UK and Papua New Guinea (4254 samples), including controls in the UK who were genotyped by the Wellcome Trust Case Control Consortium. We also did follow-up analyses of the genetic control of the clinical phenotype of prion disease and analysed candidate gene expression in a mouse ce

SUBMITTER: Mead S 

PROVIDER: S-EPMC2643048 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature