Expiratory pharyngeal narrowing during central hypocapnic hypopnea.

ABSTRACT:

Rationale

Ventilatory motor output is an important determinant of upper airway patency during sleep.

Objectives

We hypothesized that central hypocapnic hypopnea would lead to increased expiratory upper airway resistance and pharyngeal narrowing during non-REM sleep.

Methods

Noninvasive positive pressure ventilation was used to induce hypocapnic hypopnea in 20 healthy subjects. Expiratory pressure was set at the lowest pressure (2 cm H(2)O), and inspiratory pressure was increased gradually during each 3-minute noninvasive positive pressure ventilation trial by increments of 2 cm H(2)O. Analysis 1 (n = 9) included measured retropalatal cross-sectional area (CSA) using nasopharyngoscope to compare CSA at five points of the respiratory cycle between control (eupneic) and

SUBMITTER: Sankri-Tarbichi AG 

PROVIDER: S-EPMC2643080 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature