The mucosal immune response to laryngopharyngeal reflux.

ABSTRACT:

Rationale

Laryngopharyngeal reflux (LPR) affects up to 20% of Western populations. Although individual morbidity is usually moderate, treatment costs are high and there are associations with other diseases, including laryngeal cancer. To date, there have been no studies of the mucosal immune response to this common inflammatory disease.

Objectives

To determine the mucosal immune response to LPR.

Methods

We performed a prospective immunologic study of laryngeal biopsies from patients with LPR and control subjects (n = 12 and 11, respectively), and of primary laryngeal epithelial cells in vitro.

Measurements and main results

Quantitative multiple-color immunofluorescence, using antibodies for lymphocytes (CD4, CD8, CD3, CD79, CD161), granulocytes (CD68, EMBP), mo

SUBMITTER: Rees LE 

PROVIDER: S-EPMC2643204 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature