Nasal epithelial cells as surrogates for bronchial epithelial cells in airway inflammation studies.

ABSTRACT: The nose is an attractive source of airway epithelial cells, particularly in populations in which bronchoscopy may not be possible. However, substituting nasal cells for bronchial epithelial cells in the study of airway inflammation depends upon comparability of responses, and evidence for this is lacking. Our objective was to determine whether nasal epithelial cell inflammatory mediator release and receptor expression reflect those of bronchial epithelial cells. Paired cultures of undifferentiated nasal and bronchial epithelial cells were obtained from brushings from 35 subjects, including 5 children. Cells were subject to morphologic and immunocytochemical assessment. Mediator release from resting and cytokine-stimulated cell monolayers was determined, as was cell surface receptor expres

SUBMITTER: McDougall CM 

PROVIDER: S-EPMC2643208 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature