Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia.

ABSTRACT:

Rationale

The role of NADPH oxidase activation in pneumonia is complex because reactive oxygen species contribute to both microbial killing and regulation of the acute pulmonary infiltrate. The relative importance of each role remains poorly defined in community-acquired pneumonia.

Objectives

We evaluated the contribution of NADPH oxidase-derived reactive oxygen species to the pathogenesis of pneumococcal pneumonia, addressing both the contribution to microbial killing and regulation of the inflammatory response.

Methods

Mice deficient in the gp91(phox) component of the phagocyte NADPH oxidase were studied after pneumococcal challenge.

Measurements and main results

gp91(phox)(-/-) mice demonstrated no defect in microbial clearance as compared with wild-type C57

SUBMITTER: Marriott HM 

PROVIDER: S-EPMC2643216 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature