Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung.

ABSTRACT:

Rationale

Pulmonary hypertension is a common complication of chronic hypoxic lung diseases and is associated with increased morbidity and reduced survival. The pulmonary vascular changes in response to hypoxia, both structural and functional, are unique to this circulation.

Objectives

To identify transcription factor pathways uniquely activated in the lung in response to hypoxia.

Methods

After exposure to environmental hypoxia (10% O(2)) for varying periods (3 h to 2 wk), lungs and systemic organs were isolated from groups of adult male mice. Bioinformatic examination of genes the expression of which changed in the hypoxic lung (assessed using microarray analysis) identified potential lung-selective transcription factors controlling these changes in gene expression. I

SUBMITTER: Leonard MO 

PROVIDER: S-EPMC2643223 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature