Hsp40 couples with the CSPalpha chaperone complex upon induction of the heat shock response.

ABSTRACT: In response to a conditioning stress, the expression of a set of molecular chaperones called heat shock proteins is increased. In neurons, stress-induced and constitutively expressed molecular chaperones protect against damage induced by ischemia and neurodegenerative diseases, however the molecular basis of this protection is not known. Here we have investigated the crosstalk between stress-induced chaperones and cysteine string protein (CSPalpha). CSPalpha is a constitutively expressed synaptic vesicle protein bearing a J domain and a cysteine rich "string" region that has been implicated in the long term functional integrity of synaptic transmission and the defense against neurodegeneration. We have shown previously that the CSPalpha chaperone complex increases isoproterenol-mediated si

SUBMITTER: Gibbs SJ 

PROVIDER: S-EPMC2643527 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature