Streptococcus suis bacterin and subunit vaccine immunogenicities and protective efficacies against serotypes 2 and 9.

ABSTRACT: Streptococcus suis causes numerous diseases in pigs, most importantly, meningitis, arthritis, septicemia, and bronchopneumonia. One of the major problems in modern swine production is the lack of a vaccine protecting against more than one S. suis serotype. The objective of this study was to determine the protective efficacy of a serotype 2 murein-associated protein (MAP) fraction subunit vaccine in comparison to that of a bacterin against experimental challenge with serotype 2 (containing muramidase-released protein [MRP], extracellular factor, and suilysin [SLY]) and serotype 9 (containing MRP variant MRP* and SLY) strains. MAP was shown to include different surface-associated proteins, such as the MRP and surface antigen one (SAO) expressed by both pathotypes used for challenge. The resu

SUBMITTER: Baums CG 

PROVIDER: S-EPMC2643536 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature