Gene expression profiling in the human pathogenic dermatophyte Trichophyton rubrum during growth on proteins.

ABSTRACT: Dermatophytes are highly specialized filamentous fungi which cause the majority of superficial mycoses in humans and animals. The high secreted proteolytic activity of these microorganisms during growth on proteins is assumed to be linked to their particular ability to exclusively infect keratinized host structures such as the skin stratum corneum, hair, and nails. Individual secreted dermatophyte proteases were recently described and linked with the in vitro digestion of keratin. However, the overall adaptation and transcriptional response of dermatophytes during protein degradation are largely unknown. To address this question, we constructed a cDNA microarray for the human pathogenic dermatophyte Trichophyton rubrum that was based on transcripts of the fungus grown on proteins. Profiles

SUBMITTER: Zaugg C 

PROVIDER: S-EPMC2643602 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature