A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.

ABSTRACT:

Background

Genome-wide association studies (GWASs) are increasingly used to identify risk genes for complex illnesses including schizophrenia. These studies may require thousands of subjects to obtain sufficient power. We present an alternative strategy with increased statistical power over a case-control study that uses brain imaging as a quantitative trait (QT) in the context of a GWAS in schizophrenia.

Methods

Sixty-four subjects with chronic schizophrenia and 74 matched controls were recruited from the Functional Biomedical Informatics Research Network (FBIRN) consortium. Subjects were genotyped using the Illumina HumanHap300 BeadArray and were scanned while performing a Sternberg Item Recognition Paradigm in which they learned and then recognized target sets of digits i

SUBMITTER: Potkin SG 

PROVIDER: S-EPMC2643953 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature