Arabidopsis ORC1 is a PHD-containing H3K4me3 effector that regulates transcription.

ABSTRACT: Control of gene expression depends on a complex and delicate balance of various posttranslational modifications of histones. However, the relevance of specific combinations of histone modifications is not fully defined. Downstream effector proteins recognize particular histone modifications and transduce this information into gene expression patterns. Methylation of histone H3 at lysine 4 (H3K4me) is a landmark of gene expression control in eukaryotes. Its recognition depends on the presence in the effector protein of a motif termed plant homeodomain (PHD) that specifically binds to H3K4me3. Here, we establish that Arabidopsis ORC1, the large subunit of the origin recognition complex involved in defining origins of DNA replication, functions as a transcriptional activator of a subset of ge

SUBMITTER: de la Paz Sanchez M 

PROVIDER: S-EPMC2644164 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature