Gamma-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina.

ABSTRACT: Twenty-two tandemly arranged protocadherin-gamma (Pcdh-gamma) genes encode transmembrane proteins with distinct cadherin-related extracellular domains and a common intracellular domain. Genetic studies have implicated Pcdh-gamma genes in the regulation of neuronal survival and synapse formation. Because mice lacking the Pcdh-gamma cluster die perinatally, we generated conditional mutants to analyze roles of Pcdh-gamma genes in the development and function of neural circuits. Retina-specific deletion of Pcdh-gammas led to accentuation of naturally occurring death of interneurons and retinal ganglion cells (RGCs) during the first two postnatal weeks. Nonetheless, many neuronal subtypes formed lamina-specific arbors. Blocking apoptosis by deletion of the pro-apoptotic gene Bax showed that eve

SUBMITTER: Lefebvre JL 

PROVIDER: S-EPMC2644426 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature