Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance.

ABSTRACT:

Background

Amino acid insertions and deletions in proteins are considered relatively rare events, and their associations with the evolution and adaptation of organisms are not yet understood. In this study, we undertook a systematic analysis of over 214,000 polypeptides from 32 nematode species and identified insertions and deletions unique to nematode proteins in more than 1000 families and provided indirect evidence that these alterations are linked to the evolution and adaptation of nematodes.

Results

Amino acid alterations in sequences of nematodes were identified by comparison with homologous sequences from a wide range of eukaryotic (metzoan) organisms. This comparison revealed that the proteins inferred from transcriptomic datasets for nematodes contained more deletio

SUBMITTER: Wang Z 

PROVIDER: S-EPMC2644674 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature