ACE D/I polymorphism, migraine, and cardiovascular disease in women.

ABSTRACT:

Background

Interrelationships among the ACE deletion/insertion (D/I) polymorphism (rs1799752), migraine, and cardiovascular disease (CVD) are biologically plausible but remain controversial.

Methods

Association study among 25,000 white US women, participating in the Women's Health Study, with information on the ACE D/I polymorphism. Migraine and migraine aura status were self-reported. Incident CVD events were confirmed after medical record review. We used logistic regression to investigate the genotype-migraine association and proportional hazards models to evaluate the interrelationship among genotype, migraine, and incident CVD.

Results

At baseline, 4,577 (18.3%) women reported history of migraine; 39.5% of the 3,226 women with active migraine indicated aura. Durin

SUBMITTER: Schurks M 

PROVIDER: S-EPMC2644823 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature