HorkaD, a chromosome instability-causing mutation in Drosophila, is a dominant-negative allele of Lodestar.

ABSTRACT: Correct segregation of chromosomes is particularly challenging during the rapid nuclear divisions of early embryogenesis. This process is disrupted by Horka(D), a dominant-negative mutation in Drosophila melanogaster that causes female sterility due to chromosome tangling and nondisjunction during oogenesis and early embryogenesis. Horka(D) also renders chromosomes unstable during spermatogenesis, which leads to the formation of diplo//haplo mosaics, including the gynandromorphs. Complete loss of gene function brings about maternal-effect lethality: embryos of the females without the Horka(D)-identified gene perish due to disrupted centrosome function, defective spindle assembly, formation of chromatin bridges, and abnormal chromosome segregation during the cleavage divisions. These defect

SUBMITTER: Szalontai T 

PROVIDER: S-EPMC2644933 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature