Characterization of rag1 mutant zebrafish leukocytes.

ABSTRACT:

Background

Zebrafish may prove to be one of the best vertebrate models for innate immunology. These fish have sophisticated immune components, yet rely heavily on innate immune mechanisms. Thus, the development and characterization of mutant and/or knock out zebrafish are critical to help define immune cell and immune gene functions in the zebrafish model. The use of Severe Combined Immunodeficient (SCID) and recombination activation gene 1 and 2 mutant mice has allowed the investigation of the specific contribution of innate defenses in many infectious diseases. Similar zebrafish mutants are now being used in biomedical and fish immunology related research. This report describes the leukocyte populations in a unique model, recombination activation gene 1-/- mutant zebrafish (rag1

SUBMITTER: Petrie-Hanson L 

PROVIDER: S-EPMC2645361 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature