Histoplasma capsulatum proteome response to decreased iron availability.

ABSTRACT:

Background

A fundamental pathogenic feature of the fungus Histoplasma capsulatum is its ability to evade innate and adaptive immune defenses. Once ingested by macrophages the organism is faced with several hostile environmental conditions including iron limitation. H. capsulatum can establish a persistent state within the macrophage. A gap in knowledge exists because the identities and number of proteins regulated by the organism under host conditions has yet to be defined. Lack of such knowledge is an important problem because until these proteins are identified it is unlikely that they can be targeted as new and innovative treatment for histoplasmosis.

Results

To investigate the proteomic response by H. capsulatum to decreasing iron availability we have created H. capsulat

SUBMITTER: Winters MS 

PROVIDER: S-EPMC2645362 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature