A comprehensive functional analysis of tissue specificity of human gene expression.

ABSTRACT:

Background

In recent years, the maturation of microarray technology has allowed the genome-wide analysis of gene expression patterns to identify tissue-specific and ubiquitously expressed ('housekeeping') genes. We have performed a functional and topological analysis of housekeeping and tissue-specific networks to identify universally necessary biological processes, and those unique to or characteristic of particular tissues.

Results

We measured whole genome expression in 31 human tissues, identifying 2374 housekeeping genes expressed in all tissues, and genes uniquely expressed in each tissue. Comprehensive functional analysis showed that the housekeeping set is substantially larger than previously thought, and is enriched with vital processes such as oxidative phosphorylat

SUBMITTER: Dezso Z 

PROVIDER: S-EPMC2645369 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature