An evolutionary and structural characterization of mammalian protein complex organization.

ABSTRACT:

Background

We have recently released a comprehensive, manually curated database of mammalian protein complexes called CORUM. Combining CORUM with other resources, we assembled a dataset of over 2700 mammalian complexes. The availability of a rich information resource allows us to search for organizational properties concerning these complexes.

Results

As the complexity of a protein complex in terms of the number of unique subunits increases, we observed that the number of such complexes and the mean non-synonymous to synonymous substitution ratio of associated genes tend to decrease. Similarly, as the number of different complexes a given protein participates in increases, the number of such proteins and the substitution ratio of the associated gene also tends to decrease. T

SUBMITTER: Wong P 

PROVIDER: S-EPMC2645396 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature