Regional association-based fine-mapping for sodium-lithium countertransport on chromosome 10.

ABSTRACT:

Background

Increased erythrocyte sodium-lithium countertransport (SLC) has been observed in patients with essential hypertension. Consistent evidence of genetic linkage was shown for SLC on chromosome 10, and a region of interest was localized between 26 and 56 Mb.

Methods

This study surveyed single nucleotide polymorphisms (SNPs) in 54 genes that reside in the region of interest, and investigated their association with SLC and blood pressure. These SNPs were genotyped in 1,133 non-Hispanic white individuals from 255 pedigrees comprising the second phase of the Rochester Family Heart Study. The variance-components-based genetics software package SOLAR was used for evaluating whether an SNP contributed to a significant fraction of the trait heritability.

Results

Of the

SUBMITTER: Morrison AC 

PROVIDER: S-EPMC2645713 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature