Intensive multimodality treatment for children with newly diagnosed CNS atypical teratoid rhabdoid tumor.

ABSTRACT:

Purpose

Atypical teratoid rhabdoid tumor (ATRT) of the CNS is a highly malignant neoplasm primarily affecting young children, with a historic median survival ranging from 6 to 11 months. Based on a previous pilot series, a prospective multi-institutional trial was conducted for patients with newly diagnosed CNS ATRT.

Patients and methods

Treatment was divided into five phases: preirradiation, chemoradiation, consolidation, maintenance, and continuation therapy. Intrathecal chemotherapy was administered, alternating intralumbar and intraventricular routes. Radiation therapy (RT) was prescribed, either focal (54 Gy) or craniospinal (36 Gy, plus primary boost), depending on age and extent of disease at diagnosis.

Results

Between 2004 and 2006, 25 patients were enrolled;

SUBMITTER: Chi SN 

PROVIDER: S-EPMC2645855 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature