Protection from clinical peripheral sensory neuropathy in Alstrom syndrome in contrast to early-onset type 2 diabetes.

ABSTRACT:

Objective

Alström syndrome, with type 2 diabetes, and blindness could confer a high risk of foot ulceration. Clinical testing for neuropathy in Alström syndrome and matched young-onset type 2 diabetic subjects was therefore undertaken.

Research design and methods

Fifty-eight subjects with Alström syndrome (18 insulin-resistant nondiabetic and 40 diabetic; aged 8-43 years) and 30 young-onset diabetic subjects (aged 13-35 years) were studied. Neuropathy symptom questionnaires were administered. Graded monofilament and 128-MHz tuning fork vibration perception were assessed in both feet.

Results

Neuropathic symptoms, loss of monofilament, and/or vibration perception were reported by 12 of the 30 young-onset type 2 diabetic subjects (6 had neuropathic ulceration) but none

SUBMITTER: Paisey RB 

PROVIDER: S-EPMC2646029 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature