Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study.

ABSTRACT:

Objective

The RETN gene encodes the adipokine resistin. Associations of RETN with plasma resistin levels, type 2 diabetes, and related metabolic traits have been inconsistent. Using comprehensive linkage disequilibrium mapping, we genotyped tag single nucleotide polymorphisms (SNPs) in RETN and tested associations with plasma resistin levels, risk of diabetes, and glycemic traits.

Research design and methods

We examined 2,531 Framingham Offspring Study participants for resistin levels, glycemic phenotypes, and incident diabetes over 28 years of follow-up. We genotyped 21 tag SNPs that capture common (minor allele frequency >0.05) or previously reported SNPs at r2 > 0.8 across RETN and its flanking regions. We used sex- and age-adjusted linear mixed-effects models (with/witho

SUBMITTER: Hivert MF 

PROVIDER: S-EPMC2646076 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature