Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans.

ABSTRACT: Genetic variation in myostatin, a negative regulator of skeletal muscle, in cattle has shown remarkable influence on skeletal muscle, resulting in a double-muscled phenotype in certain breeds; however, DNA sequence variation within this gene in humans has not been consistently associated with skeletal muscle mass or strength. Follistatin and activin-type II receptor B (ACVR2B) are two myostatin-related genes involved in the regulation and signaling of myostatin. We sought to identify associations between genetic variation and haplotype structure in both follistatin and ACVR2B with skeletal muscle-related phenotypes. Three hundred fifteen men and 278 women aged 19-90 yr from the Baltimore Longitudinal Study of Aging were genotyped to determine respective haplotype groupings (Hap Groups) bas

SUBMITTER: Walsh S 

PROVIDER: S-EPMC2646094 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature