Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes.

ABSTRACT:

Background

There is increasing realization that regulation of genes is done partly at the RNA level by sense-antisense binding. Studies typically concentrate on the role of non-coding RNAs in regulating coding RNA. But the majority of transcripts in a cell are likely to be coding. Is it possible that coding RNA might regulate other coding RNA by short perfect sense-antisense binding? Here we compare all well-described human protein coding mRNAs against all others to identify sites 15-25 bp long that could potentially perfectly match sense-antisense.

Results

From 24,968 protein coding mRNA RefSeq sequences, none failed to find at least one match in the transcriptome. By randomizations generating artificial transcripts matched for G+C content and length, we found that there ar

SUBMITTER: Wang P 

PROVIDER: S-EPMC2646273 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature