Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution.

ABSTRACT:

Background

The physical organization and chromosomal localization of genes within genomes is known to play an important role in their function. Most genes arise by duplication and move along the genome by random shuffling of DNA segments. Higher order structuring of the genome occurs in eukaryotes, where groups of physically linked genes are co-expressed. However, the contribution of gene duplication to gene order has not been analyzed in detail, as it is believed that co-expression due to recent duplicates would obscure other domains of co-expression.

Results

We have catalogued ordered duplicated genes in Drosophila melanogaster, and found that one in five of all genes is organized as tandem arrays. Furthermore, among arrays that have been spatially conserved over longer pe

SUBMITTER: Quijano C 

PROVIDER: S-EPMC2646280 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature