Norepinephrine weaning in septic shock patients by closed loop control based on fuzzy logic.

ABSTRACT:

Introduction

The rate of weaning of vasopressors drugs is usually an empirical choice made by the treating in critically ill patients. We applied fuzzy logic principles to modify intravenous norepinephrine (noradrenaline) infusion rates during norepinephrine infusion in septic patients in order to reduce the duration of shock.

Methods

Septic patients were randomly assigned to norepinephrine infused either at the clinician's discretion (control group) or under closed-loop control based on fuzzy logic (fuzzy group). The infusion rate changed automatically after analysis of mean arterial pressure in the fuzzy group. The primary end-point was time to cessation of norepinephrine. The secondary end-points were 28-day survival, total amount of norepinephine infused and duration of

SUBMITTER: Merouani M 

PROVIDER: S-EPMC2646320 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature