MicroRNA transcriptome profiles during swine skeletal muscle development.

ABSTRACT:

Background

MicroRNA (miR) are a class of small RNAs that regulate gene expression by inhibiting translation of protein encoding transcripts. To evaluate the role of miR in skeletal muscle of swine, global microRNA abundance was measured at specific developmental stages including proliferating satellite cells, three stages of fetal growth, day-old neonate, and the adult.

Results

Twelve potential novel miR were detected that did not match previously reported sequences. In addition, a number of miR previously reported to be expressed in mammalian muscle were detected, having a variety of abundance patterns through muscle development. Muscle-specific miR-206 was nearly absent in proliferating satellite cells in culture, but was the highest abundant miR at other time points evalu

SUBMITTER: McDaneld TG 

PROVIDER: S-EPMC2646747 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature