Formal synthesis of (+/-)-roseophilin.

ABSTRACT: A formal synthesis of (+/-)-roseophilin is described. Scandium(III)-catalyzed Nazarov cyclization of 2,5-disubstituted N-tosylpyrrole 19 gives a 5,5'-fused ketopyrrole, and ansa-bridge formation via pi-allyl palladium macrocyclization gives 21.

SUBMITTER: Bitar AY 

PROVIDER: S-EPMC2646896 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature