Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood.

ABSTRACT:

Background

Atopic eczema is characterized by Th2-dominant immunity with the cytokine interleukin 13 and the transcription factor GATA binding protein 3 playing a critical role.

Objectives

We assessed the association of polymorphisms in the IL13 and GATA3 genes with childhood eczema.

Methods

A birth cohort (n = 1456) was established on the Isle of Wight in 1989 and followed at the ages of 1 (n = 1167), 2 (n = 1174), 4 (n = 1218) and 10 years (n = 1373) to determine the prevalence of allergic disease including eczema. At 4 and 10 years, skin prick testing was performed. Whole blood samples (n = 923) were obtained at the 10-year assessment, stored frozen, and genotyped. Five polymorphisms from IL13 and seven from GATA3 were genotyped for this analysis. Repeated measureme

SUBMITTER: Arshad SH 

PROVIDER: S-EPMC2647137 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature