A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder.

ABSTRACT: BACKGROUND:Melanopsin, a non-visual photopigment, may play a role in aberrant responses to low winter light levels in Seasonal Affective Disorder (SAD). We hypothesize that functional sequence variation in the melanopsin gene could contribute to increasing the light needed for normal functioning during winter in SAD. METHODS:Associations between alleles, genotypes, and haplotypes of melanopsin in SAD participants (n=130) were performed relative to controls with no history of psychopathology (n=90). RESULTS:SAD participants had a higher frequency of the homozygous minor genotype (T/T) for the missense variant rs2675703 (P10L) than controls, compared to the combined frequencies of C/C and C/T. Individuals with the T/T genotype were 5.6 times more likely to be in the SAD group than the contro

SUBMITTER: Roecklein KA 

PROVIDER: S-EPMC2647333 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature