Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.

ABSTRACT:

Background

We reviewed systematically the results of genetic studies investigating associations between putative susceptibility genes for attention-deficit hyperactivity disorder (ADHD) and neuropsychological traits relevant for this disorder.

Methods

We identified papers for review through the PubMed database.

Results

Twenty-nine studies examined 10 genes (DRD4, DAT1, COMT, DBH, MAOA, DRD5, ADRA2A, GRIN2A, BDNF and TPH2) in relation to neuropsychological traits relevant for ADHD. For DRD4, the continuous performance test (CPT) and derived tasks were the most used tests. Association of high reaction time variability with the 7-repeat allele absence appears to be the most consistent result and seems to be specific to ADHD. Speed of processing, set-shifting and cognitiv

SUBMITTER: Kebir O 

PROVIDER: S-EPMC2647566 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature