Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk.

ABSTRACT:

Background

Few epidemiologic studies have examined very high intakes of folate and whether consumption of nutrients involved in one-carbon metabolism is associated with breast cancer risk.

Objective

We prospectively examined whether the consumption of folate and nutrients involved in one-carbon metabolism (methionine, riboflavin, and vitamins B-6 and B-12) from self-reported intakes of diet (in year before baseline) and supplements (averaged over 10 y before baseline) were associated with the incidence of breast cancer and breast cancer tumor characteristics.

Design

Participants were 35,023 postmenopausal women aged 50-76 y in the VITamins And Lifestyle (VITAL) cohort study; breast cancer was diagnosed in 743 of these women between baseline (2000-2002) and 2006. Cox p

SUBMITTER: Maruti SS 

PROVIDER: S-EPMC2647765 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature