Diurnal variation of the human adipose transcriptome and the link to metabolic disease.

ABSTRACT:

Background

Circadian (diurnal) rhythm is an integral part of the physiology of the body; specifically, sleep, feeding behavior and metabolism are tightly linked to the light-dark cycle dictated by earth's rotation.

Methods

The present study examines the effect of diurnal rhythm on gene expression in the subcutaneous adipose tissue of overweight to mildly obese, healthy individuals. In this well-controlled clinical study, adipose biopsies were taken in the morning, afternoon and evening from individuals in three study arms: treatment with the weight loss drug sibutramine/fasted, placebo/fed and placebo/fasted.

Results

The results indicated that diurnal rhythm was the most significant driver of gene expression variation in the human adipose tissue, with at least 25% of

SUBMITTER: Loboda A 

PROVIDER: S-EPMC2647943 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature