Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study.

ABSTRACT:

Rationale

The comprehensive evaluation of gene variation, haplotype structure, and linkage disequilibrium is important in understanding the function of beta2-adrenergic receptor gene (ADRbeta2) on disease susceptibility, pulmonary function, and therapeutic responses in different ethnic groups with asthma.

Objectives

To identify ADRbeta2 polymorphisms and haplotype structure in white and African American subjects and to test for genotype and haplotype association with asthma phenotypes.

Methods

A 5.3-kb region of ADRbeta2 was resequenced in 669 individuals from 429 whites and 240 African Americans. A total of 12 polymorphisms, representing an optimal haplotype tagging set, were genotyped in whites (338 patients and 326 control subjects) and African Americans (222 patie

SUBMITTER: Hawkins GA 

PROVIDER: S-EPMC2648111 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature