Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease.

ABSTRACT:

Background

Chronic progressive lung disease is the most serious complication of cystic fibrosis (CF). Glutathione plays an important role in the protection of the CF lung against oxidant-induced lung injury.

Objectives

We hypothesized that a polymorphism in a novel candidate gene that regulates glutathione synthesis might influence CF lung disease.

Methods

In a cross-sectional study, subjects were recruited from CF clinics in Seattle and multiple centers in Canada. We tested for an association between CF lung disease and a functional polymorphism in the glutamate-cysteine ligase catalytic subunit (GCLC) gene. Multiple linear regression was used to test for association between polymorphisms of GCLC and severity of CF lung disease while adjusting for age, Pseudomonas ae

SUBMITTER: McKone EF 

PROVIDER: S-EPMC2648118 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature