HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques.

ABSTRACT:

Rationale

HIV-infected patients with pulmonary arterial hypertension have histologic manifestations that are indistinguishable from those found in patients with idiopathic pulmonary arterial hypertension. In addition, the role of pleiotropic viral proteins in the development of plexiform lesions in HIV-related pulmonary hypertension (HRPH) has not been explored. Simian immunodeficiency virus (SIV) infection of macaques has been found to closely recapitulate many of the characteristic features of HIV infection, and thus hallmarks of pulmonary arterial hypertension should also be found in this nonhuman primate model of HIV.

Objectives

To determine whether pulmonary arterial lesions were present in archived SIV-infected macaque lung tissues from Johns Hopkins University and two

SUBMITTER: Marecki JC 

PROVIDER: S-EPMC2648120 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature