Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits.

ABSTRACT: Inadequate remyelination of brain white matter lesions has been associated with a failure of oligodendrocyte precursors to differentiate into mature, myelin-producing cells. In order to better understand which genes play a critical role in oligodendrocyte differentiation, we performed time-dependent, genome-wide gene expression studies of mouse Oli-neu cells as they differentiate into process-forming and myelin basic protein-producing cells, following treatment with three different agents. Our data indicate that different inducers activate distinct pathways that ultimately converge into the completely differentiated state, where regulated gene sets overlap maximally. In order to also gain insight into the functional role of genes that are regulated in this process, we silenced 88 of these

SUBMITTER: Gobert RP 

PROVIDER: S-EPMC2648232 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature