Modulatory role for retinoid-related orphan receptor alpha in allergen-induced lung inflammation.

ABSTRACT:

Rationale

Nuclear receptors play a critical role in the regulation of inflammation, thus representing attractive targets for the treatment of asthma.

Objective

In this study, we assess the potential regulatory function of retinoid-related orphan receptor alpha (RORalpha) in the adaptive immune response using ovalbumin (OVA)-induced airway inflammation as a model.

Methods

Allergen-induced inflammation was compared between wild-type (WT) and staggerer (RORalpha(sg/sg)) mice, a natural mutant strain that is deficient in RORalpha expression.

Measurements and main results

Despite robust increases in OVA-specific IgE, RORalpha(sg/sg) mice developed significantly less pulmonary inflammation, mucous cell hyperplasia, and eosinophilia compared with similarly treated WT

SUBMITTER: Jaradat M 

PROVIDER: S-EPMC2648295 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature