Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice.

ABSTRACT: Resistin is an adipokine that contributes to insulin resistance in mice. In humans, however, studies investigating the link between resistin and metabolic disease are conflicting. Further complicating the matter, human resistin is produced mainly by macrophages rather than adipocytes. To address this important issue, we generated mice that lack adipocyte-derived mouse resistin but produce human resistin in a pattern similar to that found in humans, i.e., in macrophages (humanized resistin mice). When placed on a high-fat diet, the humanized resistin mice rapidly developed accelerated white adipose tissue (WAT) inflammation, leading to increased lipolysis and increased serum free fatty acids. Over time, these mice accumulated lipids, including diacylglycerols, in muscle. We found that this

SUBMITTER: Qatanani M 

PROVIDER: S-EPMC2648673 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature