Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90.

ABSTRACT: Although therapeutically targeting a single signaling pathway that drives tumor development and/or progression has been effective for a number of cancers, in many cases this approach has not been successful. Targeting networks of signaling pathways, instead of isolated pathways, may overcome this problem, which is probably due to the extreme heterogeneity of human tumors. However, the possibility that such networks may be spatially arranged in specialized subcellular compartments is not often considered in pathway-oriented drug discovery and may influence the design of new agents. Hsp90 is a chaperone protein that controls the folding of proteins in multiple signaling networks that drive tumor development and progression. Here, we report the synthesis and properties of Gamitrinibs, a class

SUBMITTER: Kang BH 

PROVIDER: S-EPMC2648691 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature