Detecting disease-associated genotype patterns.

ABSTRACT:

Background

In addition to single-locus (main) effects of disease variants, there is a growing consensus that gene-gene and gene-environment interactions may play important roles in disease etiology. However, for the very large numbers of genetic markers currently in use, it has proven difficult to develop suitable and efficient approaches for detecting effects other than main effects due to single variants.

Results

We developed a method for jointly detecting disease-causing single-locus effects and gene-gene interactions. Our method is based on finding differences of genotype pattern frequencies between case and control individuals. Those single-nucleotide polymorphism markers with largest single-locus association test statistics are included in a pattern. For a logistic reg

SUBMITTER: Long Q 

PROVIDER: S-EPMC2648768 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature