Genome-scale analysis to the impact of gene deletion on the metabolism of E. coli: constraint-based simulation approach.

ABSTRACT:

Background

Genome-scale models of metabolism have only been analyzed with the constraint-based modelling philosophy. Some gene deletion studies on in silico organism models at genome-scale have been made, but most of them were from the aspects of distinguishing lethal and non-lethal genes or growth rate. The impact of gene deletion on flux redistribution, the functions and characters of key genes, and the performance of different reactions in entire gene deletion still lack research.

Results

Three main researches have been done into the metabolism of E. coli in gene deletion. The first work was about finding key genes and subsystems: First, by calculating the deletion impact p of whole 1261 genes, one by one, on the metabolic flux redistribution of E. coli_iAF1260, we can fi

SUBMITTER: Xu Z 

PROVIDER: S-EPMC2648778 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature