Analysis on relationship between extreme pathways and correlated reaction sets.

ABSTRACT:

Background

Constraint-based modeling of reconstructed genome-scale metabolic networks has been successfully applied on several microorganisms. In constraint-based modeling, in order to characterize all allowable phenotypes, network-based pathways, such as extreme pathways and elementary flux modes, are defined. However, as the scale of metabolic network rises, the number of extreme pathways and elementary flux modes increases exponentially. Uniform random sampling solves this problem to some extent to study the contents of the available phenotypes. After uniform random sampling, correlated reaction sets can be identified by the dependencies between reactions derived from sample phenotypes. In this paper, we study the relationship between extreme pathways and correlated reaction set

SUBMITTER: Xi Y 

PROVIDER: S-EPMC2648798 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature