Genome-wide transcriptional response of an avian pathogenic Escherichia coli (APEC) pst mutant.

ABSTRACT:

Background

Avian pathogenic E. coli (APEC) are associated with extraintestinal diseases in poultry. The pstSCAB-phoU operon belongs to the Pho regulon and encodes the phosphate specific transport (Pst) system. A functional Pst system is required for full virulence in APEC and other bacteria and contributes to resistance of APEC to serum, to cationic antimicrobial peptides and acid shock. The global mechanisms contributing to the attenuation and decreased resistance of the APEC pst mutant to environmental stresses have not been investigated at the transcriptional level. To determine the global effect of a pst mutation on gene expression, we compared the transcriptomes of APEC strain chi7122 and its isogenic pst mutant (K3) grown in phosphate-rich medium.

Results

Overall, 470

SUBMITTER: Crepin S 

PROVIDER: S-EPMC2648988 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature