Upstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast.

ABSTRACT:

Background

The control of gene expression in eukaryotic cells occurs both transcriptionally and post-transcriptionally. Although many genes are now known to be regulated at the translational level, in general, the mechanisms are poorly understood. We have previously presented polysomal gradient and array-based evidence that translational control is widespread in a significant number of genes when yeast cells are exposed to a range of stresses. Here we have re-examined these gene sets, considering the role of UTR sequences in the translational responses of these genes using recent large-scale datasets which define 5' and 3' transcriptional ends for many yeast genes. In particular, we highlight the potential role of 5' UTRs and upstream open reading frames (uORFs).

Results

We

SUBMITTER: Lawless C 

PROVIDER: S-EPMC2649001 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature